With this message we wish to update you on a change in the leadership of CAPRI.

Shoshana Wodak is facing challenging family health problems and is unable to continue leading CAPRI in this important transformation period of the protein structure prediction field. She is therefore stepping down, with Alexandre Bonvin replacing her at the helm of CAPRI.

Together with Marc Lensink, Alexandre will handle the daily management of CAPRI and will be the primary contact person for targets.

To ensure the continued role of CAPRI nurturing progress in modeling protein complexes and assemblies in this new era of structural biology, it is crucial to secure a steady flow of new targets for various types of biomolecular complexes.

We therefore call for the entire CAPRI community to more proactively engage with colleagues generating experimental structures of protein complexes to offer those as targets to CAPRI.

Finally, we are happy to announce that there is a CAPRI meeting in preparation, which will most likely take place in Grenoble, France in the week of February 12, 2024. Make sure to mark the date in your calendars!

Wishing you a wonderful remainder of the summer

Shoshana, Alexandre and Marc

Prediction starts Sep 22, 2020.

A total of 4 targets: T182, T183, T184 and T185, will be offered in this Round. Three are complexes of SARS-COV-2 proteins with human host proteins (prioritized from the interaction proteomics study of Gordon et al. (2020) [1]) and the 4th target is a multi-component complex of SARS-COV-2 proteins and RNA.

All 4 targets will be released at once, with target details provided when predictions start: one week after registration starts. This Round will include, as usual, submissions by servers, human predictors, and a scoring challenge. The timelines will however be longer than for usual CAPRI targets.

Servers will be given ~3 weeks to submit models, human predictors ~10 weeks, and scorers ~4 weeks. Round 51 will be conducted in the spirit of open science. Models submitted by all groups/teams will be made immediately available online after the submission deadline in full transparency. Since for many of the considered targets, experimental structures may not be available for some time to evaluate predicted models, participating groups will work together to evaluate the quality of submitted models, compare and rank them on the basis of agreed-upon criteria and derive consensus predictions whenever appropriate. The protocol for this evaluation will be worked out after the Round is completed. We remind everyone that the plan is to report the results of this collective effort in a common publication coauthored by members of all participating groups/teams.

1. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Gordon DE et al. Nature, 583, 459-468. DOI: 10.1038/s41586-020-2286-9. Epub 2020 Apr 30.

• EMBL-EBI, Hinxton, UK, April 3-5, 2019
• About
• Sponsors
• Keynote speakers
• Program
  • Day 1
  • Day 2
  • Day 3
• Venue
• Registration
  • Abstract Submission
• Accommodations
  • Staying on-site (Hinxton)
  • Central Cambridge
  • AirBnB
  • Coach Service
• Instruct-ERIC Workshop
• Registration
• Program
  • Day 1 - 1st April 2019
  • Day 2 - 2nd April 2019
  • Coach Service
• Contact information

About

Get the latest update on the current status of computational procedures for modeling protein-protein interactions and the association of proteins with other macromolecules from this 7th CAPRI evaluation meeting. For more information - http://www.ebi.ac.uk/msd-srv/capri/

CAPRI (Critical Assessment of Predicted Interactions) is a community wide experiment designed to test methods for predicting the structure of macromolecular complexes based on the known structure of their components.

The meeting program will include an overview of the performance of protein docking and scoring procedures obtained for targets evaluated since the spring of 2013. It will also feature several plenary lectures by prominent scientists, as well as talks by the best CAPRI performers, and/or groups developing innovative computational approaches. CAPRI groups selected for oral representations will be notified, once the predictions for all outstanding targets have been completed.

We hope to see you all in Hinxton in April!

Sponsors

Keynote speakers

Madan Babu (MRC Laboratory of Molecular Biology)	Louise Walport (Francis Crick Institute)
Todd O. Yeates (University of California, Los Angeles)	John Jumper (DeepMind Technologies, UK)

Program

Day 1

Day 2

Day 3

Venue

EMBL-EBI, Hinxton, UK

European Bioinformatics Institue, EMBL-Outstation
Wellcome Trust Genome Campus
Hinxton, Cambridgeshire
CB10 1SD
United Kingdom

Registration

Registration for the 7th edition of the CAPRI evaluation meeting in Hinxton is open.

The registration fee for participants is set to £260 which includes:

3 days of scientific sessions including coffee-breaks and lunch on Wednesday, Thursday and Friday
Ongoing access to the poster area
Certificate of attendance
Conference dinner

All participants (excluding keynote speakers) are requested to pay the registration fee. Depending on availability of funds, a contribution towards travel and accommodation expenses will be provided to the selected speakers and plenary lecturers. Speakers will be notified by e-mail regarding the reimbursement policy.

Registration fee should be paid no later than 8 March 2019.

Accommodation is not included in the registration fee, but we have listed our recommendations for several hotel options in Cambridge.

Registrations are now closed.

Abstract Submission

Important guidelines for participants

A one page Abstract should be submitted for both oral and poster presentations. The deadline for Abstract submission is set to March 3 2019. Selected speakers will be notified by March 11 2019. Please email your abstract in Microsoft word format to info@bioexcel.eu.

Following the tradition of the meeting, the selected speakers will also be invited to contribute to the special issue of Proteins dedicated to CAPRI that will be published late 2019. Participants who apply for a regular talk should thus present work that is publishable and agree to contribute a manuscript for the Proteins special issue.

Accommodations

Accommodation is not provided for this event. Attendees are requested to arrange their own if required. It is strongly advised to book accommodation a month in advance as room prices tend to increase substantially closer to the date.

Staying on-site (Hinxton)

If you wish to stay in Hinxton, we recommend using the onsite accommodation - Wellcome Genome Campus Conference Centre. Book early as space is limited.

Hinxton Hall, Wellcome Genome Campus
Tel: +44(0) 1223 495 000
Fax: +44(0) 1223 495 114
conference.reception@wellcomegenomecampus.org

Central Cambridge

Holiday Inn Express Cambridge
15-17 Coldhams Park, Cambridge
Tel: +44 0871 902 1605
info@expresscambridge.co.uk

ibis Cambridge Central Station
2 Station Square, Cambridge
Tel: (+44)1223320960

Travelodge
Cambridge Leisure Park, Clifton Way, Cambridge
Tel: +44 (0)871 984 6101

AirBnB

Airbnb is a trusted community marketplace for people to list, discover, and book unique accommodation around the world. Visit https://www.airbnb.com for more information.

Coach Service

There will be a free bus service organised to/from the venue in Hinxton to multiple stops in Cambridge. The pick up and drop off points in Cambridge are - Grafton Centre, Cambridge railway station and Mowbray road. Specific details will be sent closer to the date.

Instruct-ERIC Workshop

Registration now open for the Joint Instruct-ERIC/CAPRI Workshop on Integrated Modelling of Protein-Protein Interactions Workshop. The course will run prior to the 7th CAPRI Assessment Meeting, from the 1st - 2nd April 2019 at EMBL-EBI, Hinxton, UK.

The course will consist of six sessions followed by a practical component overseen by the lecturer and an additional tutor. During the computer practicals, participants will learn to use and apply the various software with either their own data/structures, or with examples provided by the instructors.

Registration

Registration is free for participants from Instruct-ERIC countries and £250 from other countries. Visit the website to find out if you are from a participating Instruct-ERIC country. https://instruct-eric.eu/countries

Note: If you are from an Instruct-ERIC country, please select the option ‘I will pay later’ at the payment stage to register for free.

Accommodation is not included in the registration fee.

Register Now »

Program

Day 1 - 1st April 2019

Day 2 - 2nd April 2019

Coach Service

There will be a free bus service organised to/from the venue in Hinxton to Cambridge Station. Specific details will be sent closer to the date.

Contact information

Michelle Mendonca - mmendonca@ebi.ac.uk - +44 (0) 1223 494335

http://conferences.compbio.ku.edu/mpi2018

##Call for papers

The MPI conference (Charleston 2001, Stony Brook 2003, Lawrence 2005 - 2018 http://conferences.compbio.ku.edu/) plays an important role in the biomolecular modeling community, discussing current progress and setting new goals in this rapidly evolving field. As in the previous meetings, we intend to keep the focus on theoretical foundations of the field and its interface with the experimental studies.

##Organizers

Ilya Vakser, The University of Kansas Sandor Vajda, Boston University

##Program

MULTISCALE MODELING, DOCKING, FOLDING, BINDING, FUNCTION, DESIGN OF PROTEIN INTERFACES, INHIBITION OF PPI, AND MORE…

##Speakers

For the current list of our invited speakers see:
http://conferences.compbio.ku.edu/mpi2018/speakers.php

##Location

The meeting will take place at The Eldridge hotel in downtown Lawrence, KS. The Eldridge is a historic hotel in the heart of a college town with art galleries, boutique shopping, outdoor dining and live music.

##Participation

The number of participants is limited. In selecting participants, the preference will be given to those who would present a poster on the subject of the conference. If you would like to attend the conference, please submit a request as soon as possible by e-mail to Ilya Vakser (vakser@ku.edu) or Sandor Vajda (vajda@bu.edu). Include a brief (a few sentences) description of your research, your full affiliation, and position (faculty, postdoc, student, etc.). If you would like to present a poster, please include a half-page abstract. If your application is accepted, we will send you information needed for registration. The early registration fee for the participants of the conference is $390 ($290 for postdocs and students). After October 5, the fee will be $450 ($350 for postdocs and students).

We are happy to announce that the 7th CAPRI evaluation meeting will be held at the European Bioinformatics Institute (EBI), Hinxton UK, on April 3-5, 2019.

PLEASE SAVE THE DATE

As the tradition of CAPRI has it, the meeting will discuss progress achieved and remaining challenges in modeling protein interactions and assemblies. The program of the meeting will include talks by the best CAPRI performers for the evaluated targets, plenary lectures outlining recent developments likely to impact the assembly-modeling field, short talks by students and post doctoral fellows, and a lively poster session.

Further details about the meeting will be provided in the fall.

The meeting is open to anyone interested in protein docking and assembly modeling procedures.

We very much hope to see you all in Hinxton in April 2019,

The CAPRI Management Committee

For information and registration please check:

http://meetings.embo.org/event/18-biomol-interact

Proteins and their intricate network of interactions are the mainstay of any cellular process. Dissecting these networks at atomic detail is invaluable, as this paves the route to a mechanistic understanding of biological function and provides the first essential step toward the development of new drugs. Because of the challenges associated with experimental techniques, structural biologists have to resort more and more these days to complementary computational methods.

This EMBO Practical Course will present docking-based computational methods and related bioinformatics approaches, aiming at predicting how proteins interact with other biomolecules or ligands. Lectures will provide the theoretical background on state-of-the-art algorithms for sampling and scoring docking models, describe the use of low- and high-resolution information, and conservation- and coevolution-based interfaces prediction methods. Further, protein-peptide and protein-ligand interaction, as well as the young field of genome structure determination from sequencing information will also be covered to broaden the scope of the course beyond traditional protein-protein interactions.

Roughly half of the EMBO Practical Course will consist of practical sessions, during which the students will run computations on interesting biological problems. Finally, to encourage interaction between instructors and students and stimulate discussions, students will be prompted to present their own research and problems during dedicated sessions.