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CAPRI communitywide experiment on the comparative evaluation of protein-protein docking for structure prediction

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7th CAPRI evaluation meeting

EMBL-EBI, Hinxton, UK, April 3-5, 2019


About

Get the latest update on the current status of computational procedures for modeling protein-protein interactions and the association of proteins with other macromolecules from this 7th CAPRI evaluation meeting. For more information - http://www.ebi.ac.uk/msd-srv/capri/

CAPRI (Critical Assessment of Predicted Interactions) is a community wide experiment designed to test methods for predicting the structure of macromolecular complexes based on the known structure of their components.

The meeting program will include an overview of the performance of protein docking and scoring procedures obtained for targets evaluated since the spring of 2013. It will also feature several plenary lectures by prominent scientists, as well as talks by the best CAPRI performers, and/or groups developing innovative computational approaches. CAPRI groups selected for oral representations will be notified, once the predictions for all outstanding targets have been completed.

We hope to see you all in Hinxton in April!


Sponsors

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Keynote speakers

Madan Babu (MRC Laboratory of Molecular Biology) Louise Walport (Francis Crick Institute)
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Todd O. Yeates (University of California, Los Angeles) Caroline Lynn Kamerlin (Uppsala University)
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Program

Day 1

08:30 Coach from Cambridge
09:30 - 10:00 Registration
   
Welcome Address  
10:00 - 10:15 Sameer Velankar (European Bioinformatics Institute)
   
Session 1: CAPRI Targets and Evaluation Results  
   
CAPRI Prediction Results  
10:15 - 11:00 Marc Lensink (University of Lille, France)
The CAPRI-CASP Experiment  
11:00 - 11:45 Shoshana Wodak (Free University of Brussels, Belgium)
11:45 - 13:25 Poster session and lunch
   
Session 2: Highlights from CAPRI Prediction Results and Methods I  
   
13:25 - 13:50 Selected abstract talk 1
13:50 - 14:15 Selected abstract talk 2
14:15 - 14:40 Selected abstract talk 3
14:40 - 15:05 Selected abstract talk 4
   
15:05 - 15:20 Coffee break
   
Keynote Lecture I – Title TBC  
15:20 - 16:10 Madan Babu (MRC Laboratory of Molecular Biology)
   
Session 4: Themed session I  
   
16:10 - 16:25 Selected abstract talk 5
16:25 - 16:40 Selected abstract talk 6
16:40 - 16:55 Selected abstract talk 7
   
17:30 – 20:00 Poster Session and Buffet
   

Day 2

08:30 Coach from Cambridge
Keynote Lecture II – Title TBC  
09:30 - 10:20 Louise Walport (Francis Crick Institute)
   
10:20 - 10:50 Coffee break
   
Session 5: Highlights from CAPRI Prediction Results and Methods II  
   
10:50 - 11:05 Selected abstract talk 8
11:05 - 11:20 Selected abstract talk 9
11:20 - 11:35 Selected abstract talk 10
11:35 - 11:50 Selected abstract talk 11
   
11:50 - 14:00 Poster session and lunch
   
Keynote Lecture III – Title TBC  
14:00 - 14:50 Todd O. Yeates (University of California, Los Angeles)
   
14:40 - 15:05 Coffee break
   
Session 7: Themed Session II  
   
15:05 – 15:20 Selected abstract talk 12
15:20 - 15:35 Selected abstract talk 13
15:35 - 15:50 Selected abstract talk 14
15:50 - 16:05 Selected abstract talk 15
   
16:05 - 16:30 Coffee break
   
Session 8: Themed Session III  
   
16:30 - 16:45 Selected abstract talk 16
16:45 - 17:00 Selected abstract talk 17
17:00 - 17:15 Selected abstract talk 18
17:15 - 17:30 Selected abstract talk 19
   
Round Table Discussion  
17:30 - 19:00 Modeling protein assemblies and CAPRI, what next?
   
Moderator: TBC  
   
19:45 - 22:00 Conference dinner. Homerton College

Day 3

08:30 Coach from Cambridge
Keynote Lecture IV – Title TBC  
09:30 - 10:20 TBC
   
10:05 - 10:30 Coffee break
   
Session 9: Themed Session IV  
   
10:30 - 10:55 Selected abstract talk 20
10:55 - 11:20 Selected abstract talk 21
11:20 - 11:45 Selected abstract talk 22
   
11:45 - 13:00 Lunch
   
Keynote Lecture V – Title TBC  
13:00 - 13:50 TBC
   
Session 10: Themed Session V  
   
13:50 - 14:15 Selected abstract talk 23
14:15 - 14:40 Selected abstract talk 24
14:40 - 15:05 Selected abstract talk 25
   
15:05 - 15:20 Meeting closing remarks
   
15:20 - 15:40 Coffee break
   
15:40 Shuttle to Cambridge
   
16:30 Punting tour
   

Venue

EMBL-EBI, Hinxton, UK



European Bioinformatics Institue, EMBL-Outstation
Wellcome Trust Genome Campus
Hinxton, Cambridgeshire
CB10 1SD
United Kingdom


Registration

Registration for the 7th edition of the CAPRI evaluation meeting in Hinxton is now open.

The registration fee for participants is set to £260 which includes:

3 days of scientific sessions including coffee-breaks and lunch on Wednesday, Thursday and Friday
Ongoing access to the poster area
Certificate of attendance
Conference dinner

All participants (excluding keynote speakers) are requested to pay the registration fee. Depending on availability of funds, a contribution towards travel and accommodation expenses will be provided to the selected speakers and plenary lecturers. Speakers will be notified by e-mail regarding the reimbursement policy.

Registration fee should be paid no later than 28 February 2019. Late registration after that date will however remain possible.

Accommodation is not included in the registration fee, but we have listed our recommendations for several hotel options in Cambridge.

Register Now »

Abstract Submission

Important guidelines for participants

A one page Abstract should be submitted for both oral and poster presentations. The deadline for Abstract submission is set to February 28 2019. Selected speakers will be notified by March 11 2019. Please email your abstract in Microsoft word format to info@bioexcel.eu.

Following the tradition of the meeting, the selected speakers will also be invited to contribute to the special issue of Proteins dedicated to CAPRI that will be published late 2019. Participants who apply for a regular talk should thus present work that is publishable and agree to contribute a manuscript for the Proteins special issue.


Accommodations

Accommodation is not provided for this event. Attendees are requested to arrange their own if required. It is strongly advised to book accommodation a month in advance as room prices tend to increase substantially closer to the date.

Staying on-site (Hinxton)

If you wish to stay in Hinxton, we recommend using the onsite accommodation - Wellcome Genome Campus Conference Centre. Book early as space is limited.

Hinxton Hall, Wellcome Genome Campus
Tel: +44(0) 1223 495 000
Fax: +44(0) 1223 495 114
conference.reception@wellcomegenomecampus.org

Central Cambridge

Holiday Inn Express Cambridge
15-17 Coldhams Park, Cambridge
Tel: +44 0871 902 1605
info@expresscambridge.co.uk

ibis Cambridge Central Station
2 Station Square, Cambridge
Tel: (+44)1223320960

Travelodge
Cambridge Leisure Park, Clifton Way, Cambridge
Tel: +44 (0)871 984 6101

AirBnB

Airbnb is a trusted community marketplace for people to list, discover, and book unique accommodation around the world. Visit https://www.airbnb.com for more information.

Coach Service

There will be a free bus service organised to/from the venue in Hinxton to multiple stops in Cambridge. The pick up and drop off points in Cambridge are - Grafton Centre, Cambridge railway station and Mowbray road. Specific details will be sent closer to the date.


Instruct-ERIC Workshop

Registration now open for the Joint Instruct-ERIC/CAPRI Workshop on Integrated Modelling of Protein-Protein Interactions Workshop. The course will run prior to the 7th CAPRI Assessment Meeting, from the 1st - 2nd April 2019 at EMBL-EBI, Hinxton, UK.

The course will consist of six sessions followed by a practical component overseen by the lecturer and an additional tutor. During the computer practicals, participants will learn to use and apply the various software with either their own data/structures, or with examples provided by the instructors.


Registration

Registration is free for participants from Instruct-ERIC countries and £250 from other countries. Visit the website to find out if you are from a participating Instruct-ERIC country. https://instruct-eric.eu/countries

Please note accommodation is not included in the registration fee.

Register Now »

Registrations close 8 March 2019.


Program

Introduction to protein-protein docking: sampling and scoring  
Practical: Flexible docking with SwarmDock  
Paul A. Bates, and Raphael A.G. Chaleil, Francis Crick Institute, London, UK  
   
Introduction to data-driven docking  
Practical: Integrative docking with HADDOCK  
Alexandre M.J.J. Bonvin and Panos Koukos, Bijvoet Center for Biomolecular Research, Utrecht, NL  
   
Protein structure prediction  
Practical: Modelling protein structures and variants: Phyre, PhyreRisk, Missense3D and EzMol  
Michael J.E. Sternberg, Lawrence Kelley and Charles Tochukwu, Imperial College London, London, UK  
   
The validation and verification of protein structure  
Practical: Hands-on assessment of structural quality  
Gerard Kleywegt, EMBL European Bioinformatics Institute, Cambridge, UK  
   
Integrative structure determination of macromolecular assemblies  
Practical: Determination of macromolecular structure using Cryo-EM data  
Sony Malhotra, Institute of Structural and Molecular Biology, London, UK  
   
Protein-protein binding affinities  
Practical: Modelling interaction strength using machine learning  
Iain H. Moal, EMBL European Bioinformatics Institute, Cambridge, UK  
   

Sponsored by:

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Contact information

Michelle Mendonca - mmendonca@ebi.ac.uk - +44 (0) 1223 494335